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. 2023 Jan 13;14(1):26. doi: 10.1038/s41419-022-05534-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A The expression of SF3B4 was downloaded and then analyzed from the TCGA database in normal (n = 72) and ccRCC (n = 533) tissues. B The mRNA levels of SF3B4 were detected by RT-qPCR in total 53 clinical samples. C Three groups of ccRCC and normal renal tissue were randomly selected and western blot was used to detect SF3B4 protein expression. D Hematoxylin and eosin (HE) staining of tumor and normal kidney tissues. Scale bar = 50 μm. E Immunohistochemical staining examined the SF3B4 expression in clinical samples. Scale bar = 50 μm. F–I The mRNA levels of SF3B4 were compared with different clinicopathological parameters from TCGA‐KIRC: cancer versus normal tissues, G stage, T stage, N stage, and M stage. j RT-qPCR detected the SF3B4 expression in the ccRCC tissues of metastasis (n = 21) and non-metastasis (n = 21). K Poor prognosis and low overall survival were associated with high SF3B4 expression in TCGA‐KIRC. All data are expressed as the mean ± SEM of three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001 vs. their corresponding controls.