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. 2023 Jan 13;14:201. doi: 10.1038/s41467-023-35795-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a PTM-activated degron: Writer enzymes generate PTMs at specific residues within target proteins that are recognized by an E3 ubiquitin ligase complex for proteasome degradation. PTM-activated degron is a natively inactive degron structure, modified, or otherwise activated by the addition of one or more PTMs, ultimately leading to the proteolytic degradation of a protein. b PTM-inactivated degron: PTMs added to specific sites on protein substrates to inhibit their interaction with the protein degradation machinery. PTM-inactivated degron is a destabilization motif that is inactivated by the addition of one or more PTMs.