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. 2023 Jan 13;14:201. doi: 10.1038/s41467-023-35795-8

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Fig. 2 — Lysine and arginine methylation regulates the function of protein by altering stability. Of note, lysine methylation converts protein stability negatively by methyl-degron (light green) and arginine methylation mainly increases protein stabilization by methyl-inactivated degron (dark green). Methyltransferase EZH2, G9a, and SETD7 modify lysine site via mono-methylation and further stimulate poly-ubiquitination of substrates by reader protein such as DCAF1 and L3MBTL3.