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. 2023 Jan 13;14:201. doi: 10.1038/s41467-023-35795-8

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Fig. 3 — Various different molecular mechanisms for PTMs changing a protein’s proteolytic stability have been found. DTL (for Denticleless protein homolog, also called CDT2) is the human orthologue of yeast Sic1 and itself a substrate adapter of the DCX E3 ligase complex. DTL is phosphorylated at T464, which promotes interaction with 14-3-3, thus shielding it from degradation by SCF^FBXO11^44,167.