Table 1.
List of methyl-activated and -inactivated degron with corresponding writer and eraser
| Substrate | Activated/ inactivated Degron | Lys/ Arg | Site (Me) | Mono/di/tri | Methyl-transferase (Writer) | Demethylase (Eraser) | Site (Ub) |
|---|---|---|---|---|---|---|---|
| HIF1α | Activated | Lys | K32 | me1 | SETD7 | LSD1 | K532/K538/K547 |
| DNMT1 | Activated | Lys | K142 | me1 | SETD7 | LSD1 | C-terminus |
| E2F1 | Activated | Lys | K185 | me1 | SETD7 | LSD1 | K161/K164 |
| p65 | Activated | Lys | K314/K315 | me1 | SETD7 | - | K28/K62/K195 |
| FOXO3 | Activated | Lys | K271 | me1 | SET7 | - | K242/K259/K290/K569 |
| RORα | Activated | Lys | K38 | me1 | Ezh2 | - | C-terminus |
| FOXO1 | Activated | Lys | K273 | me1 | G9a | - | K245/K248 |
| ERα | Inactivated | Lys | K302 | me1 | SETD7 | - | K302 |
| p53 | Inactivated | Lys | K372 | me1 | SETD7 | - | K370/K372/K373/K381/K382 |
| PRMT6 | Inactivated | Arg | R35 | me1, 2 | PRMT6 | - | - |
| KLF4 | Inactivated | Arg | R374/R376/R377 | me1, 2 | PRMT5 | - | K43 |
| SRC-3 | Inactivated | Arg | R1171 | me1, 2 | CARM1 | - | K723/K786 |
| Axin | Inactivated | Arg | R378 | me1, 2 | PRMT1 | - | K789/K821 |