Table 1.
The degree of value of PPI networks.
| No. | Target | Degree of value | No. | Target | Degree of value |
|---|---|---|---|---|---|
| 1 | AKT1 | 28 | 19 | VDR | 12 |
| 2 | IL6 | 26 | 20 | CYP1A1 | 11 |
| 3 | PPARG | 26 | 21 | CYP3A4 | 11 |
| 4 | JUN | 25 | 22 | GSK3B | 11 |
| 5 | EGFR | 22 | 23 | HDAC3 | 10 |
| 6 | CASP3 | 20 | 24 | TLR9 | 10 |
| 7 | PTGS2 | 20 | 25 | NR1H4 | 9 |
| 8 | RELA | 20 | 26 | G6PD | 7 |
| 9 | TLR4 | 20 | 27 | NOX1 | 7 |
| 10 | CXCL8 | 19 | 28 | HDAC5 | 6 |
| 11 | NFE2L2 | 19 | 29 | ADRB2 | 5 |
| 12 | HDAC1 | 18 | 30 | GPBAR1 | 5 |
| 13 | AHR | 17 | 31 | CYP1A2 | 4 |
| 14 | IL2 | 17 | 32 | CYP2D6 | 4 |
| 15 | MAPK14 | 15 | 33 | HDAC9 | 4 |
| 16 | MAPK8 | 15 | 34 | CTSD | 3 |
| 17 | HDAC2 | 12 | 35 | HCAR2 | 3 |
| 18 | MAPK1 | 12 | 36 | RORA | 1 |
HDAC5, histone deacetylase 5; ADRA2B, alpha-2B adrenergic receptor; HCAR2, hydroxycarboxylic acid receptor 2; ADRB2, adrenoceptor beta 2; HDAC3, histone deacetylase 3; HDAC2, histone deacetylase 2; HDAC1, histone deacetylase 1; CTSD, cathepsin D; IL2, interleukin 2; TLR4, toll-like receptor 4; TLR9, toll-like receptor 9; AKT1, AKT serine/threonine kinase 1; EGFR, epidermal growth factor receptor; CXCL8, C-X-C motif chemokine ligand 8; PTGS2, prostaglandin-endoperoxide synthase 2; MAPK8, mitogen-activated protein kinase 8; IL6, interleukin-6; JUN, jun proto-oncogene, AP-1 transcription factor subunit; GSK3B, glycogen synthase kinase-3 beta; RELA, RELA proto-oncogene, NF-KB subunit; MAPK14, mitogen-activated protein kinase 14; CASP3, caspase 3; MAPK1, mitogen-activated protein kinase 1.