Table 2.
The targets of 41 signaling pathways related to NAFLD.
| KEGG ID and description | Target genes | False discovery rate |
|---|---|---|
| hsa04620: Toll-like receptor signaling pathway | MAPK1, AKT1, RELA, JUN, MAPK8, IL6, CXCL8, TLR4, TLR9, MAPK14 | 5.19E−10 |
| hsa04657: IL-17 signaling pathway | MAPK1, RELA, GSK3B, JUN, MAPK8, IL6, PTGS2, CXCL8, MAPK14, CASP3 | 3.26E−13 |
| hsa04933: AGE-RAGE signaling pathway in diabetic complications | MAPK1, AKT1, CASP3, RELA, JUN, MAPK8, IL6, CXCL8, MAPK14, NOX1 | 4.70E−13 |
| hsa04668: TNF signaling pathway | MAPK1, AKT1, RELA, JUN, MAPK8, IL6, PTGS2, MAPK14, CASP3 | 3.02E−11 |
| hsa04917: Prolactin signaling pathway | AKT1, RELA, GSK3B, MAPK8, MAPK14, MAPK1 | 6.52E−08 |
| hsa04660: T cell receptor signaling pathway | MAPK1, AKT1, RELA, JUN, GSK3B, MAPK1, MAPK14, MAPK8 | 5.3E−10 |
| hsa04625: C-type lectin receptor signaling pathway | MAPK1, AKT1, RELA, JUN, IL6, PTGS2, MAPK8, IL2, MAPK14 | 1.58E−11 |
| hsa04012: ErbB signaling pathway | MAPK1, AKT1, JUN, GSK3B, EGFR, MAPK8 | 0.000000156 |
| hsa04664: Fc epsilon RI signaling pathway | MAPK1, AKT1, MAPK14, MAPK8 | 0.0000462 |
| hsa04066: HIF-1 signaling pathway | MAPK1, AKT1, RELA, EGFR, IL6, TLR4 | 0.000000552 |
| hsa05120: Epithelial cell signaling in Helicobacter pylori infection | RELA, JUN, MAPK8, CXCL8, EFGR, MAPK14, CASP3 | 1.5E−09 |
| hsa04722: Neurotrophin signaling pathway | MAPK1, AKT1, RELA, JUN, MAPK8, MAPK14 | 3.34E−08 |
| hsa04662: B cell receptor signaling pathway | MAPK1, AKT1, RELA, JUN, GSK3B | 0.00000319 |
| hsa04370: VEGF signaling pathway | MAPK1, AKT1, PTGS2, MAPK14 | 0.0000278 |
| hsa04071: Sphingolipid signaling pathway | MAPK1, AKT1, MAPK1, MAPK8, MAPK14, CTSD | 0.000000861 |
| hsa04068: FoxO signaling pathway | MAPK1, AKT1, IL6, MAPK8, EGFR, MAPK14 | 0.00000132 |
| hsa04919: Thyroid hormone signaling pathway | MAPK1, AKT1, HDAC1, HDAC2, HDAC3, GSK3B | 0.000000974 |
| hsa04064: NF-kappa B signaling pathway | RELA, PTGS2, CXCL8, TLR4 | 0.0002 |
| hsa04920: Adipocytokine signaling pathway | AKT1, RELA, MAPK8 | 0.0011 |
| hsa04062: Chemokine signaling pathway | MAPK1, AKT1, RELA, GSK3B, CXCL8 | 0.00013 |
| hsa04630: JAK-STAT signaling pathway | AKT1, IL2, IL6, EGFR | 0.00092 |
| hsa04926: Relaxin signaling pathway | MAPK1, AKT1, RELA, JUN, MAPK8, MAPK14, EGFR | 6.55E−08 |
| hsa04622: RIG-I-like receptor signaling pathway | RELA, MAPK8, MAPK14, CXCL8 | 0.0000547 |
| hsa04621: NOD-like receptor signaling pathway | RELA, JUN, MAPK8, IL6, CXCL8, TLR4, MAPK14, MAPK1 | 2.15E−08 |
| hsa04915: Estrogen signaling pathway | MAPK1, AKT1, JUN, EGFR, CTSD | 0.0000312 |
| hsa04024: cAMP signaling pathway | MAPK1, AKT1, RELA, JUN, MAPK8, HCAR2, ADRB2 | 0.00000112 |
| hsa04910: Insulin signaling pathway | MAPK1, AKT1, GSK3B, MAPK8 | 0.000052 |
| hsa04072: Phospholipase D signaling pathway | MAPK1, AKT1, EGFR, CXCL8 | 0.00071 |
| hsa04150: mTOR signaling pathway | MAPK1, AKT1, GSK3B | 0.0083 |
| hsa04912: GnRH signaling pathway | MAPK1, JUN, MAPK8, EGFR, MAPK14 | 0.00000565 |
| hsa04151: PI3K-Akt signaling pathway | MAPK1, AKT1, RELA, GSK3B, IL2, EGFR, IL6, TLR4 | 0.00000224 |
| hsa04010: MAPK signaling pathway | MAPK1, AKT1, RELA, JUN, MAPK8, EGFR, MAPK14, CASP3 | 0.000000606 |
| hsa04921: Oxytocin signaling pathway | MAPK1, JUN, EGFR, PTGS2 | 0.00073 |
| hsa04371: Apelin signaling pathway | MAPK1, AKT1, HDAC5 | 0.0059 |
| hsa04014: Ras signaling pathway | MAPK1, AKT1, RELA, MAPK8, EGFR | 0.00031 |
| hsa04022: cGMP-PKG signaling pathway | MAPK1, AKT1, ADRB2, ADRA2B | 0.00094 |
| hsa04261: Adrenergic signaling in cardiomyocytes | MAPK1, AKT1, MAPK14, ADRB2 | 0.00071 |
| hsa04015: Rap1 signaling pathway | AKT1, MAPK14, EGFR | 0.0019 |
| hsa04550: Signaling pathways regulating pluripotency of stem cells | MAPK1, AKT1, MAPK14, GSK3B | 0.00062 |
| hsa04330: Notch signaling pathway | HDAC1, HDAC2 | 0.012 |
| hsa04310: Wnt signaling pathway | JUN, MAPK8, GSK3B | 0.0087 |
HDAC5, histone deacetylase 5; ADRA2B, alpha-2B adrenergic receptor; HCAR2, hydroxycarboxylic acid receptor 2; ADRB2, adrenoceptor beta 2; HDAC3, histone deacetylase 3; HDAC2, histone deacetylase 2; HDAC1, histone deacetylase 1; CTSD, cathepsin D; IL2, interleukin 2; TLR4, toll-like receptor 4; TLR9, toll-like receptor 9; AKT1, AKT serine/threonine kinase 1; EGFR, epidermal growth factor receptor; CXCL8, C-X-C motif chemokine ligand 8; PTGS2, prostaglandin-endoperoxide synthase 2; MAPK8, mitogen-activated protein kinase 8; IL6, interleukin-6; JUN, jun proto-oncogene, AP-1 transcription factor subunit; GSK3B, glycogen synthase kinase-3 beta; RELA, RELA proto-oncogene, NF-KB subunit; MAPK14, mitogen-activated protein kinase 14; CASP3, caspase 3; MAPK1, mitogen-activated protein kinase 1.