Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jan 13;14:200. doi: 10.1038/s41467-023-35806-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 7 — a, b Upregulation of IL-13 mRNA expression upon blunt, closed TBI in mouse (3 h post injury). Chemogenetic suppression of inhibitory PV interneurons enhances the upregulation of IL-13 mRNA at baseline and after trauma (Saline Sham vs Saline TBI: p < 0.0001; Saline Sham vs PSEM Sham: p = 0.0150; Saline TBI vs PSEM TBI: p = 0.0742). N = 3; n = SS: 332; ST: 422; PS: 382; PT: 319 neurons. c, d Neuronal nuclear calcium buffering (PV.NLS) strongly reduces IL-13 mRNA at baseline and upon TBI (Control Sham vs Control TBI: p = 0.0141; Control Sham vs PV.NLS Sham: p = 0.00141; Control TBI vs PV.NLS TBI: p = 0.0069). N = 3; n = MS: 427; MT: 394; PS: 215; PT: 385 neurons. Scale bar: 20 μm. *: p < 0.05; **: p < 0.01; ****: p < 0.0001. b, d One-way ANOVA with Sidak’s multiple comparison. Source data are provided as a Source Data file.