TABLE 3.
Reactivity of antisera with whole cells of meningococci determined by immunofluorescencea
| Formulation | Immunofluorescence reactivityb on whole cells
|
||||
|---|---|---|---|---|---|
| MC58 Opc++ | MC139 Opc++ | MC139 Opc+ | H44/76 Opc+ | MC114 Opc− | |
| Opc+Al(OH)3 | − | − | − | − | − |
| Opc-liposomes | + | − | − | −/+ | − |
| Opc+MPLA-liposomes | ++ | + | − | −/+ | − |
| Opc-liposomes+MPLA-liposomes | ++ | + | − | −/+ | − |
| Opc-Zwit | ++ | +/− | − | −/+ | − |
| Opc+MPLA-Zwit | ++ | + | − | −/+ | − |
| Liposomes (empty) | − | − | − | − | − |
| MPLA-liposomes (empty) | − | − | − | − | − |
| Normal mouse serum | − | − | − | − | − |
a
Antisera were reacted with whole cells of the homologous and heterologous strains. Strains MC58 and H44/76 expressed the homologous Opc protein, and strain MC139 expressed a heterologous protein. The five patterns of reactivity observed are illustrated in Fig. 2.
b
Symbols are defined in the legend to Fig. 2.