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. 2023 Jan 13;13(1):e1180. doi: 10.1002/ctm2.1180

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© 2023 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Roles of long‐chain acyl‐coenzyme A synthases 5 (ACSL5) and phosphoinositide 3‐kinase (PI3K) and ERK signal pathways in lipidomic alterations induced by lysophosphatidylcholine (lysoPC). Regulatory effects of ACSL5 and PI3/K/ERK signal pathways in lysoPC‐influenced triacylglycerol (TAG)‐lysoPC balance were investigated, by measuring TAG (A) and lysoPC (B) in ACSL5 ^NC or ACSL5 ^KD cells treated with vehicle or lysoPC, TAG (C) and lysoPC (D) in ACSL5 ^NC or ACSL5 ^OE cells treated with vehicle or lysoPC, TAG (E) and lysoPC (F) in SPC‐A1 cells pretreated with vehicle or LY294002 and TAG (G) and lysoPC (H) in SPC‐A1 cells pretreated with vehicle or GDC0994 (n = 6 per group). * and ** or # and ## stand for the p‐values less than .05 and .01, respectively, as compared with cells treated with vehicle or lysoPC