Table 3.
The incidence and severity of histopathological lesions in testes of male mice treated with cyclophosphamide (CP) and/or China dust (CD)
| Group | ||||||
|---|---|---|---|---|---|---|
| Findings | Grade | NC | CP | CD 40 | CP + CD 20 | CP + CD 40 |
| Testis | ||||||
| Exfoliation of spermatogenic cells | - | 6 | 3 | 6 | 0 | 0 |
| + | 0 | 3 | 0 | 5 | 1 | |
| ++ | 0 | 0 | 0 | 1 | 5 | |
| Degeneration of spermatogonia | - | 6 | 0 | 6 | 0 | 0 |
| + | 0 | 4 | 0 | 0 | 0 | |
| ++ | 0 | 2 | 0 | 6 | 4 | |
| +++ | 0 | 0 | 0 | 0 | 2 | |
| Decrease of spermatogonia | - | 6 | 0 | 6 | 0 | 0 |
| + | 0 | 4 | 0 | 0 | 0 | |
| ++ | 0 | 2 | 0 | 6 | 3 | |
| +++ | 0 | 0 | 0 | 0 | 3 | |
| Degeneration of spermatocytes | - | 6 | 0 | 6 | 0 | 0 |
| + | 0 | 4 | 0 | 0 | 0 | |
| ++ | 0 | 2 | 0 | 6 | 4 | |
| +++ | 0 | 0 | 0 | 0 | 2 | |
| Decrease of spermatocytes | - | 6 | 0 | 6 | 0 | 0 |
| + | 0 | 4 | 0 | 0 | 0 | |
| ++ | 0 | 2 | 0 | 6 | 4 | |
| +++ | 0 | 0 | 0 | 0 | 2 | |
| Vacuolation of Sertoli cells | - | 6 | 2 | 6 | 0 | 0 |
| + | 0 | 4 | 0 | 4 | 0 | |
| ++ | 0 | 0 | 0 | 2 | 2 | |
| +++ | 0 | 0 | 0 | 0 | 4 | |
Grades are as follows: -, normal; +, slight; ++, moderate; and +++, severe change