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PK parameters of doxetaxel after administration of CKD-516 and docetaxel in female SD rats
| PK parameter | Docetaxel | |
|---|---|---|
| Vehicle + docetaxel group | CKD-516 + docetaxel group | |
| T1/2(hr) | 8.7 | 5.0 |
| Tmax(hr) | 1.0 | 1.0 |
| Cmax(ng/mL) | 469 | 578 |
| AUC0~24 h(ng·hr/mL) | 1893 | 1933 |
| AUCinf(ng·hr/mL) | 2137 | 2022 |
