TABLE 3.
Serum O and Vi antibody responses in mice immunized with a single i.n. dose of CVD 908-htrA or CVD 909a
| Strain or control | Serum IgG anti-Vi
|
Serum IgG anti-O
|
||||
|---|---|---|---|---|---|---|
| Day 0 GMT | Day 23 GMT (range) | Frequency of seroconversionb (%) | Day 0 GMT | Day 23 GMT (range) | Frequency of seroconversion (%)bc | |
| CVD 908-htrA | 10 | 49 a (20–160) | 9/10 b (90) | 31 | 87 (20–320) | 3/6 (50) |
| CVD 909 | 10 | 160 d (80–640) | 10/10 e (100) | 32 | 80 (20–160) | 4/9 (44) |
| PBS | 10 | 10 | 0/10 f (0) | 26 | 25 (20–40) | 0/7 (0) |
a
a versus d, P = 0.0007, Mann-Whitney test; b versus f, P < 0.001, Fisher's exact test; e versus f, P < 0.0001, Fisher's exact test.
b
Number of mice which seroconverted per total number tested.
c
Some mice had insufficient quantities of serum remaining for testing O antibody.