TABLE 4.
Efficacy of CVD 908-htrA and CVD 909 in protecting mice against intraperitoneal challenge with wild-type serovar Typhi suspended in hog gastric mucin, 4 weeks after a single i.n. immunization
| Strain or control | Mortalitya (%) | % Vaccine efficacy |
|---|---|---|
| CVD 908-htrA | 9/10 a (90) | 10 |
| CVD 909b | 3/8 b (38) | 62 |
| PBS | 10/10 c (100) | 0 |
a
Number of mice that died per total number tested. a versus c, P = 0.0043, Fisher's exact test; b versus c, P = 0.0065, Fisher's exact test.
b
Two mice allocated to this group died during handling prior to challenge.