Figure 3. Summary of MSC-derived extracellular vesicles in the treatment of bone diseases. Natural/genetic or chemically-modified MSC-derived extracellular vesicles can regulate a series of biological processes by carrying RNA and protein to target cells, and exert therapeutic effects on bone diseases. GPNMB: glycoprotein nonmelanoma clone B; lncRNA: long non-coding RNA; MALAT1: metastasis-associated lung adenocarcinoma transcript 1; MSC: mesenchymal stem cell. This figure was created using Servier Medical Art templates (https://smart.servier.com).