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In vitro gene silencing by mannose-siRNA conjugates in M1 macrophages
M1 macrophages were treated with 20 μg/mL of hexa-mannose-siCD45 or tetra-GalNAc-siCD45 either alone or in combination with 100 μg/mL of mannose- or GalNAc- ERP. Cell lysates were collected at 24 h post conjugate treatment and the target gene silencing activity was assessed by quantification of mRNA with QuantiGene assay (n = 3, ∗∗∗p < 0.01, two-way ANOVA analysis). The error bars represent standard deviation.
