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. 2022 Aug 17;31(1):211–229. doi: 10.1016/j.ymthe.2022.08.012

Figure 7.

Figure 7

Grafted iPSC-CMs in the rat myocardium within the infarct region and border zone reveal neoangiogenesis 4 weeks post transplantation

(A) Representative confocal images showing the expression of α-SMA and CD31 in the infarct zone (IZ). α-SMA, red; CD31, green; DAPI, blue; n = 5; scale bar, 100 μm; zoom-in scale bar, 15 μm. (B) Representative confocal images showing the expression of α-SMA and CD31 in the border zone (BZ). α-SMA, red; CD31, green; DAPI, blue; scale bar, 100 μm; zoom in scale bar, 15 μm. Note: the images in the left panel in (7A) and (7B) are identical since there is no infarct or border zone in the Sham group. (C and D) Quantitative analysis of CD31-positive capillary density (C) and CD31/α-SMA-positive arteriole density (D) in the infarct zone. (E and F) Quantitative analysis of CD31-positive capillary density (E) and CD31/α-SMA-positive arteriole density (F) in the border zone. All data are means ± SD. NS indicates p > 0.05, ∗p < 0.05, ∗∗p < 0.01.