Figure 2.

Cell type-enriched WGCNA modules were identified

(A and B) Cell-type enrichment analysis with cell type-enriched genes of brain cell types (A) and neuronal subtypes (B) was conducted on 43 co-expressed gene modules constructed by WGCNA. The-log10 (p-value) value is shown (BHA p< 0.05, Fisher’s exact test). Cell type-enriched modules (BHA p< 1 × 10⁻²) for each cell type hardly overlapped, even in glutamatergic and GABAergic neurons. Oligodendrocyte- and microglia-enriched genes were exclusively enriched in one module for each cell type, but many modules were enriched for astrocytes and neurons.