Figure 8.

Functional annotation of neuronal cell type-related modules

(A–D) Functional enrichment analysis with genes related to GO terms and KEGG pathways on the glutamatergic (A and B) and GABAergic (C and D) neuron modules. The five most significant terms (p< 0.05) are shown in each category. GO: gene ontology, BP: biological process, CC: cellular component, MF: molecular function, KEGG: Kyoto Encyclopedia of Genes and Genomes pathway. M24 and M26 were enriched for neurodevelopment-related terms (“cell projection morphogenesis”, “muscle organ development”, and “growth cone” in M24, and “neuron development”, “neuron projection development”, “central nervous system neuron differentiation”, and “filopodium” in M26). M24 was enriched for a dendrite-related term (“dendritic shaft”), whereas M26 was enriched for axon-related terms (“axon”, “delayed rectifier potassium channel activity”, “ephrin receptor activity”, and “axon guidance”). M32 was enriched for synapse-related terms (“secretion by cell”, “regulation of neurotransmitter levels”, “presynapse”, “syntaxin-1 binding”, and “synaptic vesicle cycle”). M42 was enriched for calcium–calmodulin signaling-related terms (“cAMP metabolic process”, “calmodulin binding”, and “calcium signaling pathway”).