Fig. 1.

A human LysRS crystal structure with asymmetric substrate binding states. (A) Overall view of the structure (pdb: 6ILD) in one asymmetric unit. The LysRS dimer is shown as a transparent surface and cartoons (green and cyan). The cocrystallized AIMP2 N-terminal peptide is shown as pink sticks. (B–C) Electron density maps of the enzymatic pockets 1 and 2 of the LysRS dimer are shown as blue meshes. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)