Table 3.
Top 10 enriched pathways in the Co-DEmiRNA-gene network
| KEGG pathway | Value |
|---|---|
| Focal adhesion | 5.34e−05 |
| ECM-receptor interaction | 0.000264 |
| Pathways in cancer | 0.00109 |
| Melanoma | 0.00121 |
| Small cell lung cancer | 0.00222 |
| Glioma | 0.0104 |
| p53 signaling pathway | 0.0117 |
| mRNA surveillance pathway | 0.0194 |
| TGF-beta signaling pathway | 0.0207 |
| Asthma | 0.0484 |
| Reactome pathway | |
| Signaling by SCF-KIT | 1.43E−05 |
| Oncogene Induced Senescence | 1.70E−05 |
| Pre-NOTCH Transcription and Translation | 4.81E−05 |
| PI3K events in ERBB4 signaling | 7.45E−05 |
| PIP3 activates AKT signaling | 7.45E−05 |
| PI3K events in ERBB2 signaling | 7.45E−05 |
| PI-3K cascade:FGFR1 | 7.45E−05 |
| PI-3K cascade: FGFR2 | 7.45E−05 |
| PI-3K cascade:FGFR3 | 7.45E−05 |
| PI-3K cascade:FGFR4 | 7.45E−05 |
| GO-BP | |
| Negative regulation of cellular process | 1.76e−05 |
| Ras protein signal transduction | 1.78e−05 |
| Neurogenesis | 3.82e−05 |
| Generation of neurons | 6.59e−05 |
| Response to external stimulus | 0.000108 |
| Skeletal system development | 0.000116 |
| Neuron projection development | 0.000123 |
| Nervous system development | 0.000136 |
| Regulation of cell proliferation | 0.000193 |
| Negative regulation of biological process | 0.000207 |
| GO-MF | |
| Growth factor binding | 1.03e−05 |
| Extracellular matrix structural constituent | 1.65e−05 |
| Transcription from RNA polymerase II promoter | 0.000364 |
| Nucleotide binding | 0.00263 |
| Protein phosphatase type 2A regulator activity | 0.00346 |
| Negative regulation of transcription DNA-dependent | 0.0054 |
| Purine ribonucleotide binding | 0.00642 |
| Purine nucleotide binding | 0.00661 |
| Protein serine/threonine kinase activity | 0.00759 |
| Protein serine/threonine/tyrosine kinase activity | 0.0101 |
| GO-CC | |
| Growth factor binding | 1.03e−05 |
| Extracellular matrix structural constituent | 1.65e−05 |
| Transcription from RNA polymerase II promoter | 0.000364 |
| Nucleotide binding | 0.00263 |
| Protein phosphatase type 2A regulator activity | 0.00346 |
| Negative regulation of transcription, DNA-dependent | 0.0054 |
| Purine ribonucleotide binding | 0.00642 |
| Purine nucleotide binding | 0.00661 |
| Protein serine/threonine kinase activity | 0.00759 |
| Protein serine/threonine/tyrosine kinase activity | 0.0101 |