Table 4.
Top 10 enriched pathways in the Co-DEmiRNA-TF network
| KEGG pathway | Value |
|---|---|
| Acute myeloid leukemia | 2.72E−08 |
| Pathways in cancer | 5.71E−06 |
| Chronic myeloid leukemia | 0.000286 |
| Epstein-Barr virus infection | 0.000549 |
| Transcriptional misregulation in cancer | 0.000553 |
| Adipocytokine signaling pathway | 0.00604 |
| Pancreatic cancer | 0.00721 |
| Small cell lung cancer | 0.00961 |
| Toxoplasmosis | 0.0128 |
| Jak-STAT signaling pathway | 0.0145 |
| Reactome pathway | |
| Pathways in cancer | 0.000125 |
| Legionellosis | 0.00247 |
| Renal cell carcinoma | 0.00549 |
| Adipocytokine signaling pathway | 0.00604 |
| Apoptosis | 0.0103 |
| TGF-beta signaling pathway | 0.0106 |
| MAPK signaling pathway | 0.0117 |
| Chagas disease (American trypanosomiasis) | 0.0118 |
| Toxoplasmosis | 0.0128 |
| Toll-like receptor signaling pathway | 0.0139 |
| GO-BP | |
| Positive regulation of transcription from RNA polymerase II promoter | 1.71e−11 |
| Positive regulation of transcription, DNA-dependent | 1.52e−09 |
| Positive regulation of transcription, DNA-dependent | 1.52e−09 |
| Positive regulation of RNA metabolic process | 2.68e−09 |
| Positive regulation of the nucleobase-containing compound metabolic process | 8.02e−09 |
| Regulation of transcription from RNA polymerase II promoter | 1.69e−08 |
| Positive regulation of cellular metabolic process | 5.23e−08 |
| Transcription from RNA polymerase II promoter | 1e−07 |
| Positive regulation of metabolic process | 1.04e−07 |
| Regulation of multicellular organismal process | 1.14e−06 |
| GO-MF | |
| Positive regulation of transcription, DNA-dependent | 1.33e−09 |
| Transcription from RNA polymerase II promoter | 8.8e−08 |
| Sequence-specific DNA binding | 5.2e−07 |
| Transcription factor binding | 1.41e−06 |
| DNA binding | 2.8e−06 |
| Negative regulation of transcription, DNA-dependent | 6.39e−05 |
| Chromatin binding | 0.00237 |
| Protein heterodimerization activity | 0.00316 |
| Double-stranded DNA binding | 0.00649 |
| Protein dimerization activity | 0.00704 |
| GO-CC | |
| Transcription factor complex | 4.72e−05 |
| Nucleoplasm | 8.93e−05 |
| Nucleoplasm part | 0.000275 |
| Nuclear lumen | 0.00106 |
| Chromatin | 0.00143 |
| Nuclear part | 0.00388 |
| Organelle lumen | 0.00426 |
| Membrane-enclosed lumen | 0.00472 |
| Chromosomal part | 0.0108 |
| Chromosome | 0.0166 |