Note. Path diagrams depicting mediation relationships between Sexual Orientation (SO), Psychosocial adversity (PSA), Substance use (SU) and Lifetime Sexual Partners (LSP) latent factors, standardized variance component influences on latent factors and standardized path coefficients. Factors were scaled by fixing one loading per factor to 1. SO = Sexual orientation, Dep = Depressive symptoms, Anx = Generalized anxiety symptoms, ELA = Early-life adversity, IPV = Intimate partner violence, Drg = Other illicit drug use, Alc = Alcohol Use, Can = Cannabis use. Af1-Af4, Cf1-Cf4 and Ef1-Ef4 = Factor-specific additive genetic and shared and individual-specific environmental influences respectively (in blue). As2-As8, Cs2-Cs8 and Es2-Es8 = Variable-specific additive genetic, shared and individual-specific environmental influences respectively (in red). Solid lines indicate significant paths while dotted lines indicate nonsignificant paths.