Table 2.
Nanoparticles in medical devices (2017–2022).
| Indication | Medical Device | Nano-application | Stage | Reference |
|---|---|---|---|---|
| Intracranial Aneurysm | 2nd Gen platinum coil (HES™, MicroVention, Inc) | Second generation contains hydrogel polymer coating that enhances packing density and healing, and reduces recurrence | Clinical Trial/Completed (NCT01407952) | Bendok et al. (2020) |
| Polymer-modified coils (Matrix™) | PGA/PLA coating to improve clot organization inside the cavity | Phase 4/Completed (NCT00396981) | McDougall et al. (2021) | |
| Woven EndoBridge (WEB) Aneurysm Embolization System | Self-expanding embolization implants made of braided nitinol/platinum wires which are highly conformable and visible on fluoroscopy | Clinical Trial/Active (NCT02191618) | Arthur et al. (2019) | |
| Magnetic Bacterial Nano-cellulose (BNC) | PEG-coated BNC magnetization via SPIO to create local and focal attraction force of cells for reconstruction of tunica media | In vitro | Echeverry-Rendon et al. (2017) | |
| Magnetic Particle Imaging (MPI) | SPIOs to visualize lumen of nitinol flow diverter stents without relevant stent-induced artifacts | Material development | Herzberg et al. (2021) | |
| Subarachnoid Hemorrhage | Drug-eluting stent | MSNs with paclitaxel within electrospun PLA fibers for better endothelialization and prevention of lumen stenosis | In vivo (canine) | Zhang et al. (2019) |
| Vascular access | Peripherally inserted central catheters (PICC) | PVA-based hydrogel coating to reduce thrombus accumulation than uncoated polyurethane catheter | In vitro | Mannarino et al. (2020) |
| Urinary Tract Obstruction | Ureteral Stents | kanamycin-chitosan nanoparticles (KMCSNPs) immobilized on polyurethane ureteral stent (PUS) to increase antibacterial activity of chitosan NP stent and prevent urinary tract-associated infection | In vitro | Venkat Kumar et al. (2016) |
| Ureteral Stents | hyperbranched poly(amide-amine)-capped Ag@Au NP-embedded fiber membrane-structured PGA/PLGA ureteral stent as a dual biodegradable and contact-killing antimicrobial ureteral stent | In vivo (pig) | Gao et al. (2020) | |
| Prosthetic Joint Infection | Bone cement | PC-SeNP to improve antibacterial and antioxidant properties of commercially-available bone cements | In vitro | Karahaliloglu and Kilicay (2020) |
| Bone cancer | Cemex (Tecres Company) | gentamicin+AgNP+CuNP for increased bactericidal properties and improve cytocompatibility of commercially available bone cement | In vitro | Wekwejt et al. (2019) |
Abbreviations: PGA: poly(glycolic acid); PLA: poly(lactic acid); PEG: poly(ethylene glycol); SPIO: superparamagnetic iron oxide; MSN: mesoporous silica nanoparticles; PVA: poly(vinyl alcohol); Ag@AuNP: silver shell and gold core nanoparticle PC: phosphatidylcholine; SeNP: selenium nanoparticle; AgNP: silver nanoparticle; CuNP: copper nanoparticle; PLGA: poly(lactic-co-glycolic acid)