Table 4:

Multivariable^a hazard ratio (95% CI) for risk of frailty according to categories of cumulative average leisure time physical activity in women ≥60y stratified by lean body mass and age^b

		Quintiles of physical activity (MET hours/wk)
	1	2	3	4	5	P trend	P interaction
Total MET hours/wk
Lean body mass < median	1	0.74 (0.69, 0.80)	0.65 (0.60, 0.70)	0.54 (0.50, 0.58)	0.44 (0.40, 0.48)	<0.001
Lean body mass >= median	1	0.80 (0.76, 0.84)	0.71 (0.67, 0.75)	0.63 (0.59, 0.67)	0.51 (0.47, 0.55)	<0.001	0.002
Age <70 y	1	0.70 (0.64, 0.75)	0.59 (0.53, 0.64)	0.48 (0.43, 0.53)	0.40 (0.36, 0.45)	<0.001
Age >= 70y	1	0.81 (0.77, 0.85)	0.73 (0.69, 0.77)	0.64 (0.60, 0.67)	0.51 (0.47, 0.54)	<0.001	<0.001
Moderate activity MET hours/wk
Lean body mass < median	1	0.76 (0.71, 0.82)	0.71 (0.66, 0.77)	0.61 (0.56, 0.66)	0.49 (0.45, 0.54)	<0.001
Lean body mass >= median	1	0.81 (0.77, 0.85)	0.73 (0.69, 0.77)	0.64 (0.60, 0.68)	0.53 (0.49, 0.58)	<0.001	0.33
Age <70 y	1	0.74 (0.69, 0.81)	0.62 (0.56, 0.67)	0.53 (0.48, 0.58)	0.47 (0.41, 0.53)	<0.001
Age >= 70y	1	0.82 (0.78, 0.86)	0.77 (0.73, 0.81)	0.67 (0.63, 0.70)	0.53 (0.49, 0.56)	<0.001	<0.001
Vigorous activity MET hours/wk
Lean body mass < median	1	0.92 (0.86, 0.99)	0.81 (0.75, 0.87)	0.75 (0.70, 0.82)	0.70 (0.65, 0.77)	<0.001
Lean body mass >= median	1	0.90 (0.85, 0.95)	0.87 (0.83, 0.92)	0.83 (0.78, 0.88)	0.79 (0.73, 0.85)	<0.001	0.004
Age <70 y	1	0.84 (0.77, 0.91)	0.76 (0.70, 0.83)	0.72 (0.66, 0.79)	0.64 (0.57, 0.71)	<0.001
Age >= 70y	1	0.94 (0.89, 0.99)	0.89 (0.84, 0.93)	0.83 (0.79, 0.88)	0.79 (0.75, 0.84)	<0.001	<0.001
			Activity duration	(hour/wk)
	<1.0	1 to <3.0	3.0 to <7.0	7.0 to <10.0	≥10.0
Physical Activity time
Lean body mass < median	1	0.72 (0.67, 0.77)	0.55 (0.51, 0.59)	0.43 (0.38, 0.48)	0.35 (0.30, 0.40)	<0.001
Lean body mass >= median	1	0.79 (0.75, 0.83)	0.63 (0.60, 0.67)	0.50 (0.45, 0.55)	0.47 (0.41, 0.53)	<0.001	0.02
Age <70 y	1	0.70 (0.65, 0.76)	0.50 (0.46, 0.54)	0.43 (0.37, 0.50)	0.40 (0.34, 0.48)	<0.001
Age >= 70y	1	0.80 (0.76, 0.84)	0.64 (0.61, 0.68)	0.49 (0.45, 0.53)	0.41 (0.36, 0.46)	<0.001	<0.001
	<1.0	1 to < 2.0	2 to < 4.0	≥4.0
Moderate activity time
Lean body mass < median	1	0.81 (0.75, 0.86)	0.69 (0.64, 0.74)	0.58 (0.53, 0.63)		<0.001
Lean body mass >= median	1	0.80 (0.76, 0.84)	0.72 (0.69, 0.76)	0.59 (0.55, 0.64)		<0.001	0.25
Age <70 y	1	0.75 (0.70, 0.81)	0.62 (0.57, 0.67)	0.56 (0.50, 0.63)		<0.001
Age >= 70y	1	0.83 (0.79, 0.87)	0.74 (0.71, 0.78)	0.59 (0.55, 0.63)		<0.001	<0.001
Vigorous activity time
Lean body mass < median	1	0.80 (0.74, 0.85)	0.78 (0.72, 0.84)	0.67 (0.60, 0.74)		<0.001
Lean body mass >= median	1	0.88 (0.84, 0.93)	0.86 (0.80, 0.91)	0.76 (0.69, 0.83)		<0.001	0.005
Age <70 y	1	0.81 (0.74, 0.88)	0.70 (0.63, 0.77)	0.73 (0.63, 0.84)		<0.001
Age >= 70y	1	0.86 (0.82, 0.90)	0.87 (0.82, 0.92)	0.71 (0.65, 0.77)		<0.001	<0.001

^aMultivariable adjusted for age, BMI, energy intake, alcohol intake, AHEI-2010 score, post-menopausal hormone use, smoking, highest degree earned, use of the following medications: aspirin, beta blockers, hydrochlorthiazide, ACE inihibitors, calcium channel blockers, other antihypertensive medications, insulin, oral hypoglycemics, lipid lowering medication. Moderate and vigorous activities were mutually adjusted for each other.

^bLean body mass < median: case = 6129, Lean body mass >= median: case= 10,350; age < 70y: case= 4406, age >=70: case= 12,073