FIGURE 8.

Relation of baseline alterations with MoCA subscore trajectory. In Parkinson’s disease (PD) patients, relation between baseline striatal volume with (A) attention/executive (att/exec) subscore trajectories and (B) memory subscore trajectories, baseline frontostriatal white matter (FSWM) fractional anisotropy (FA) with (C) att/exec subscore trajectories and (D) memory subscore trajectories, baseline hippocampal volume with (E) attention/executive (att/exec) subscore trajectories and (F) memory subscore trajectories, and baseline fornix FA with (G) attention/executive (att/exec) subscore trajectories and (H) memory subscore trajectories. The bold lines represent the expected trajectory for a 65-year-old woman at 4.1 years disease duration with a baseline metric 1 standard deviation (SD) above the sample mean (green) and 1 SD below the sample mean (red). The low/high value for each metric is 6748/8098 mm² for striatum, 0.37/0.42 for FSWM FA, 3692/4370 mm³ for hippocampal volume, and 0.26/0.29 for fornix FA. Shading represents the standard error of the mean of the outcome variable. MoCA subscore was the outcome variable. Baseline age, baseline disease duration, sex, baseline MRI metric, study time, and the study time × baseline MRI interaction term were the fixed effects. Intercept and slope were the random effects for each PD participant. Asterisk (*) indicates a significant (p < .05) association between the MRI metric and MoCA subscore at baseline. p_ia represents effect of baseline metric on slope of cognitive metric. Attention/executive subscore is the sum of trails, clock, digits, vigilance, and serial 7s, and memory subscore is the sum of delayed recall and orientation.