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. Author manuscript; available in PMC: 2023 Jan 15.
Published in final edited form as: Med. 2022 Nov 22;4(1):31–50.e8. doi: 10.1016/j.medj.2022.11.002

Figure 6.

Figure 6.

PAL variants are detargeted from several key peripheral organs in cynomolgus macaques.

(A-H) Fold difference in within-individual hFXN mRNA expression (top panel of each frame) and vector genome abundance (bottom panel of each frame) from different variants normalized to AAV9 in cynomolgus macaque peripheral organs. Dashed red line represents AAV9-CBh-hFXN expression or vector genome abundance normalized to 1. Data are represented as mean ± SD (n=3); *p<0.05, **p<0.01 (one-way ANOVA with Dunnett’s MCT and AAV9 as the control).