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. Author manuscript; available in PMC: 2024 Feb 1.
Published in final edited form as: Immunology. 2022 Oct 11;168(2):331–345. doi: 10.1111/imm.13587

Figure 5. Impaired intratumoral immunity enhances MTAP-deficient tumor growth.

Figure 5.

(A, D) Percentage of immune cell populations within CD45+ TILs from CL1-0 WT/KO (A) and CL1-5 Mock/MTAP (D) tumors of humanized mice was assessed by CyTOF analysis (four mice per group). Others: unspecified human CD45+ TILs. (B, E) Main sub-populations of CD45+ TILs from CL1-0 WT/KO (B) and CL1-5 Mock/MTAP (E) tumors of humanized mice derived from CyTOF analysis were shown as t-SNE plots. (C, F) t-SNE plots displaying the expression levels of immune cell markers in CD45+ TILs from CL1-0 WT/KO (C) and CL1-5 Mock/MTAP (F) tumors of humanized mice. Bottom bars: the relative intensities of markers in CD45+ TILs from CL1-0 WT (blue) and KO (red) tumors, or CL1-5 Mock (red) and MTAP (blue) tumors.