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. Author manuscript; available in PMC: 2024 Feb 15.
Published in final edited form as: Int J Cardiol. 2022 Nov 29;373:7–16. doi: 10.1016/j.ijcard.2022.11.047

Table 2.

Association Between Progenitor Cells and Outcomes (n=1366)

Outcome HR (95% CI), P Value Cell Type Continuous unadjusted* Continuous adjusted* Median unadjusted Median adjusted Threshold cutoff, Using ROC unadjusted ** Threshold cutoff, Using ROC adjusted **
Model 1: Individual PC subtypes
Death CD34+ 1.03 (1.00–1.07), 0.07 1.03 (0.99 – 1.08), 0.16 1.42 (1.08–1.85), 0.01 1.53 (1.10–2.10), 0.001 1.70 (1.28–2.25), 0.0002 1.67 (1.21–2.31), 0.002
CD34+/CD133+ 1.04 (1.01–1.07), 0.01 1.04 (1.00– 1.07), 0.03 1.28 (0.98–1.67), 0.07 1.14 (0.83–1.56), 0.42 1.48 (1.14–1.92), 0.004 1.38 (1.01–1.89), 0.04
CD34+/CXCR4+ 1.04 (1.02–1.07), 0.0007 1.05 (1.00– 1.08), 0.001 1.53 (1.17–2.00), 0.002 1.46 (1.06–2.01), 0.02 1.52 (1.17–1.99), 0.002 1.47 (1.08–2.02), 0.01
CD34+/VEGFR2+ 1.01 (0.99–1.01), 0.11 1.01 (0.99–1.02), 0.12 1.53 (1.17–2.01), 0.0019 1.59 (1.15–2.18), 0.004 1.58 (1.2–2.06), 0.0009 1.70 (1.25–2.31), 0.0008
CV death/MI CD34+ 1.03 (1.00–1.07), 0.07 1.04 (0.99–1.06), 0.08 1.17 (0.87–1.57), 0.29 1.20 (0.85–1.71), 0.30 1.61 (1.16–2.18), 0.003 1.64 (1.14–2.38), 0.008
CD34+/CD133+ 1.04 (1.02–1.06), 0.001 1.04 (1.02–1.06), 0.0002 1.11 (0.83–1.50), 0.48 1.01 (0.71–1.41), 0.98 1.34 (1.00–1.81), 0.05 1.30 (0.92–1.83), 0.13
CD34+/CXCR4+ 1.04 (1.02–1.08), 0.003 1.06 (1.02–1.10), 0.005 1.44 (1.07–1.95), 0.02 1.50 (1.04–2.17), 0.03 1.46 (1.08–1.97), 0.01 1.51 (1.08–2.11), 0.02
CD34+/VEGFR2+ 1.01 (0.99–1.02), 0.16 1.01 (0.99–1.02), 0.17 1.36 (1.01–1.84), 0.04 1.47 (1.01–2.13), 0.04 1.48 (1.10–2.00), 0.01 1.54 (1.07–2.21), 0.02

Adjusted for age, body mass index, sex, race, smoking history, history of myocardial infarction, hypertension, diabetes, hyperlipidemia, renal function (GFR), obstructive coronary artery disease, left ventricular ejection fraction and statin use.

*

Log-transformed cell counts (log2[cells]). Values reported = 1/HR (1/upper CI–1/lower CI), P

**

Cutoffs used were 1032 cells/milliliter for CD34+ cells, 625 cells/milliliter for CD34+/CD133+ cells, 25 cells/milliliter for CD34+/VEGFR2+ cells and 794 cells/milliliter for CD34+/CXCR+ cells (see Methods section of this article).