Table 3.
Association Between both CD34+/CXCR4+ and CD34+/VEGFR2+ Cells and Outcomes (n=1366)
| Outcome HR (95% CI), P Value | Cell Type | Continuous Adjusted* | Median Adjusted | Threshold cutoff, Using ROC adjusted ** |
|---|---|---|---|---|
| Death | CD34+/CXCR4+ | 1.05 (1.01–1.08), 0.007 | 1.27 (0.93–1.74), 0.13 | 1.32 (0.97–1.80), 0.08 |
| CD34+/VEGFR2+ | 1.01 (1.00–1.01), 0.23 | 1.51 (1.09–2.11), 0.01 | 1.61 (1.17–2.21), 0.003 | |
| CV death/MI | CD34+/CXCR4+ | 1.05 (1.01–1.10), 0.01 | 1.35 (0.95–1.92), 0.10 | 1.46 (1.03–2.06), 0.03 |
| CD34+/VEGFR2+ | 1.00 (0.99–1.01), 0.42 | 1.44 (0.97–2.12), 0.07 | 1.41 (0.98–2.03), 0.07 | |
| Outcome | Categorical PC Score*** | Threshold cutoff, Unadjusted | Threshold cutoff, Adjusted | |
| Death | 1 vs. 0 | 1.61 (1.17–2.21), 0.003 | 1.80 (1.27–2.55), 0.001 | |
| 2 vs. 0 | 2.06 (1.48–2.88), <0.0001 | 2.08 (1.42–3.03), 0.0002 | ||
| CV Death/MI | 1 vs. 0 | 1.38 (0.97–1.96), 0.08 | 1.55 (1.05–2.28), 0.03 | |
| 2 vs. 0 | 1.82 (1.24–2.66), 0.002 | 2.03 (1.30–3.17), 0.002 |
Model includes clinical covariates as above plus CD34+/VEGFR2+ and CD34+/CXCR4+. Adjusted for age, body mass index, sex, race, smoking history, history of myocardial infarction, hypertension, diabetes, hyperlipidemia, renal function (GFR), obstructive coronary artery disease, left ventricular ejection fraction and statin use.
Log-transformed cell counts (log2[cells]). Values reported = 1/HR (1/upper CI–1/lower CI), P
Cutoffs used were 25 cells/milliliter for CD34+/VEGFR2+ cells and 794 cells/milliliter for CD34+/CXCR+ cells (see Methods section of this article).
Progenitor Cell score based on number of PC subtypes (CD34+/CXCR4+ or CD34+/VEGF2R+) below threshold ROC cutoff (score of 2) compared to reference group with both above threshold cutoff (score of 0). Cell counts based on threshold cutoffs (794 cells/mL for CD34+/CXCR4+ cells and 25 cells/mL for CD34+/VEGF2R+ cells)