Table 1.
Highlighted Human Temporal Bone Studies for Neglected Otologic Diseases
| Autoimmune inner ear disease (AIED) | ||
|---|---|---|
| Study | Sample | SV Findings |
| Schuknecht and Nadol (1994) | n=1 (AIED) | Atrophy of SV (1/1) |
| Sone et al. (1999) | n=5 (SLE) | Atrophy of SV (4/5) |
| Calzada et al. (2012) | n=4 (SS) | Atrophy of SV (4/4) |
| Di Stadio and Ralli (2017) | n=113 (SLE: 52, GPA: 22, SS: 20, Cogan: 8, AIED: 7) | Atrophy of SV (37/113) |
| Meniere’s Disease (MD) | ||
| Study | Sample | SV Findings |
| Kariya et al. (2009) | n=14 | Decreased mean number of blood vessels within SV (p<0.05) |
| Kariya et al. (2007) | n=14 | Atrophy of SV along ower middle turn (p<0.001) and apical turn (p=0.012) |
| Masutani et al. (1992) | n=8 | Fewer vessels with smaller crosssectional area of vessels within SV (p<0.05) |
| Ishiyama et al. (2007) | n=4 | Average of 21% decrease in volume of SV compared to control (p=0.01) |
| Merchant et al. (2005) | n=2 | Atrophy of SV (1/2) |
| Vasama et al. (1999) | n=21 | Decreased normal SV in MD compared to control (61% vs. 77%, p<0.05) |
| Fraysse et al. (1980) | n=17 | Atrophy of SV in “most cases” (not specified) |
| Sudden Sensorineural Hearing Loss (SSNHL) | ||
| Study | Sample | SV Findings |
| Merchant et al. (2005) | n=17 | Atrophy of SV (10/17) |
| Schuknecht and Donovan (1986) | n=12 | Atrophy of SV (6/12) |
| Yoon et al. (1990) | n=11 | Atrophy of SV (7/11) |
| Vasama et al. (2000) | n=12 | Atrophy of SV (12/12) |
| Khetarpal et al. (2015) | n=18 | Atrophy of SV (18/18) |
| Bahmad (2008) | n=1 | Atroiphy of SV (1/1) |
| Cytomegalovirus-related Hearing Loss (CRHL) | ||
| Study | Sample | SV Findings |
| Teissier et al. (2011) | n=6 (CMV infected human fetus) | Viral inclusions predominating in the marginal cell layer of the SV (5/6) |
| Gabrielli et al. (2013) | n=20 (CMV infected human fetus) | CMV infection identified in marginal cell of SV in 45%(9/20) of fetuses |
| Tsuprun et al. (2019) | n=2 (CMV infected human fetus) | Hypervascularization and enlarged blood vessesls in SV at all turns (1/2) |
*
Autoimmune inner ear disease (AIED), autoinflammatory inner ear disease (AID), systemic lupus erythematosus (SLE), Sjogren’s syndrome (SS), Meniere’s disease (MD), stria vascularis (SV), sudden sensorineural hearing loss (SSNHL), CMV-related hearing loss (CHRL), cytomegalovirus (CMV)