Figure 5.

(A) Ahr and (B) Cyp1a1 expression after exposure to CS and treatment with C. intybus leaf extract. CS and C. intybus leaf extract changed Ahr and Cyp1a1 gene transcriptional activity in testicular tissue of Wistar rats. CS resulted in the upregulation of Ahr and Cyp1a1 in the smoke group. These modulations were significant in Ahr and Cyp1a1 expression. Simultaneous treatment with C. intybus leaf extract resulted in a significant reduction in gene expression. Values are presented as mean±SEM (n=6 / group). Differences between groups were compared by one-way ANOVA and Tukey's test. *statistically different from the control group (p<0.5), +statistically different from the smoke group (p<0.5), #statistically different from the smoke+extract group (p<0.5). CS: cigarette smoke, Ahr: Aryl hydrocarbon receptor, Cyp1a1: Cytochrome P450, family 1, subfamily a, polypeptide 1