Table 3.
Predictive Indices of Corticosteroid Failure in Acute Severe Ulcerative Colitis Patients and the Need for “Rescue Therapy”
| Index | Criteria | Predictive indices of corticosteroid failure in acute severe ulcerative colitis |
|---|---|---|
| Travis or Oxford criteria21 | Stool frequency >8/day or stool frequency >3/day with CRP >45 mg/L on day 3 of IV corticosteroid |
If any present on day 3 (85% probability of colectomy) |
| Ho or Scottish22 | Colonic dilatation >5.5 cm (4 points) Albumin <3 g/dL on admission (1 point) Average daily number of stool over first 3 days: <4 (0 points), 4–6 (1 point), 6–9 (2 points), >9 (4 points) |
≥4 Points on day 3 (85% probability of nonresponse) |
| Lindgren23 | Serum CRP (mg/L)×0.14+stool frequency on day 3 of IV corticosteroid | >8 Points on day 3 (72% probability of nonresponse) |
| Seo24 | The calculated score according to following variables; hematochezia, stool frequency, ESR, hemoglobin, and albumin | >180 Seo index on 2 weeks after corticosteroid probability of colectomy |
| Jain25 | A UCEIS >6 at admission and FC >1,000 µg/g on day 3 | Predictors of steroid failure and need for rescue therapy/colectomy |
CRP, C-reactive protein; IV, intravenous; ESR, erythrocyte sedimentation rate; UCEIS, Ulcerative Colitis Endoscopic Index of Severity; FC, fecal calprotectin.