Table 2.
Pharmacokinetic Parameters of Tegoprazan and M1 Following a Single Oral Dose of 50, 100, or 200 mg of Tegoprazan
| Parameter | Tegoprazan | M1 | |||||
|---|---|---|---|---|---|---|---|
| 50 mg (n=12) | 100 mg (n=12) | 200 mg (n=12) | 50 mg (n=12) | 100 mg (n=12) | 200 mg (n=12) | ||
| Cmax, ng/mL | 383±112 | 970±185 | 1,859±461 | 141±47 | 319±99 | 660±222 | |
| AUClast, ng∙hr/mL | 2,469±616 | 5,385±1,190 | 11,512±2,647 | 2,104±704 | 4,790±963 | 10,113±2,787 | |
| tmax, hr | 1.84 (0.83–3.00) | 1.42 (0.83–3.00) | 1.83 (0.87–2.00) | 11.90 (1.83–12.02) | 2.85 (2.83–12.00) | 7.42 (2.83–12.00) | |
Data are presented as mean±SD or median (range).
Cmax, maximum concentration; AUClast, area under the plasma concentration versus time curve from time 0 to the last measurable concentration; tmax, time of the maximum measured plasma concentration.