Table 5.
Evaluation of Immunohistochemical Markers and Distant Organ Metastasis
| IHC marker | No. (%) | p-value | ||
|---|---|---|---|---|
| Locoregional recurrence (n=16) |
Distant metastasis (n=44) |
|||
| E-cadherin | 0 | 0 | 1 (2) | 1.000 |
| 1–3 | 16 (100) | 43 (98) | ||
| Snail | 0 | 1 (6) | 13 (29) | 0.086 |
| 1–3 | 15 (94) | 31 (71) | ||
| IL-6 | 0 | 11 (69) | 14 (42) | 0.010 |
| 1–3 | 5 (31) | 30 (58) | ||
| EGFR-M | 0–2 | 13 (81) | 32 (73) | 0.738 |
| 3 | 3 (19) | 12 (27) | ||
| EGFR-C | 0–2 | 9 (56) | 22 (50) | 0.668 |
| 3 | 7 (44) | 22 (50) | ||
IHC, immunohistochemistry; E-cadherin, epithelial cadherin; IL-6, interleukin-6; EGFR-M, membranous epidermal growth factor receptor; EGFR-C, cytoplasmic epidermal growth factor receptor.