Table 4.
Cox Proportional Hazards Model of the Factors Associated with Overall Survival in Patients with Non-GCLS (n=920)
| Factor | Univariate analysis | Multivariate analysis* | |||
|---|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | ||
| Age | 1.047 (1.031–1.062) | <0.001 | 1.039 (1.025–1.054) | <0.001 | |
| Sex (male) | 1.509 (1.054–2.159) | 0.025 | |||
| EBV and HP coinfection | |||||
| Others | 1 | ||||
| EBV+/HP+ | 3.488 (0.488–24.929) | 0.213 | |||
| EBV infection | 0.353 (0.088–1.427) | 0.144 | |||
| HP infection | 0.763 (0.552–1.056) | 0.102 | |||
| Tumor location | |||||
| Upper third | 1 | ||||
| Middle third | 0.402 (0.258–0.627) | <0.001 | |||
| Lower third | 0.422 (0.286–0.624) | <0.001 | |||
| Tumor size | 1.200 (1.160–1.241) | <0.001 | 1.082 (1.026–1.141) | 0.003 | |
| Number of lesions | 0.336 (0.047–2.398) | 0.277 | |||
| AJCC stage | |||||
| I | 1 | 1 | |||
| II | 3.929 (2.448–6.308) | <0.001 | 2.433 (1.437–4.120) | 0.001 | |
| III | 12.472 (8.414–18.487) | <0.001 | 6.165 (3.630–10.470) | <0.001 | |
| LVi | 4.563 (3.251–6.406) | <0.001 | |||
| PNi | 4.723 (3.406–6.549) | <0.001 | 1.631 (1.099–2.420) | 0.015 | |
GCLS, gastric carcinoma with lymphoid stroma; HR, hazard ratio; CI, confidence interval; EBV, Epstein-Barr virus; HP, Helicobacter pylori; AJCC, American Joint Committee on Cancer; LVi, lymphovascular invasion; PNi, perineural invasion.
*Simultaneously, adjusted for age, sex, EBV infection, tumor location, tumor size, AJCC stage, LVi, and PNi.