Table 1.
Factor | Non OSA (n = 11) | Mild OSA (n = 11) | Moderate OSA (n = 11) | Severe OSA (n = 15) | P |
---|---|---|---|---|---|
Demographics | |||||
Age (years) | 38(33–40) | 38(33–49) | 40(35–51) | 35(30–45) | 0.542 |
Gender (males) | 7(64%) | 6(55%) | 9(82%) | 15(100%)* | 0.014 |
BMI (Kg/m2) | 24.01 ± 3.11 | 26.33 ± 2.29 | 26.49 ± 3.68 | 28.72 ± 3.38* | 0.006 |
Hypertension (%) | 0(0%) | 2(18%) | 3(27%) | 4(27%) | 0.302 |
Diabetes (%) | 0(0%) | 1(9%) | 1(9%) | 4(27%) | 0.266 |
PSG date | |||||
AHI (events/h) | 2.1 (1.5–2.5) | 6.6(5.4–10.3)* | 18.7(16.7–20.6)* | 59.1 (54.6–73.0)* | < 0.001 |
Mean SaO2 (%) | 95 (95–97) | 95(94–96) | 95(94–96) | 93(88–94)* | < 0.001 |
Lowest SaO2 (%) | 90(86–93) | 87(83–88) | 82(75–85)* | 63(52–75)* | < 0.001 |
Intestinal barrier markers | |||||
D-LA (mmol/L) | 1.40(0.01–2.74) | 7.73(4.19–11.52)* | 7.88(6.09–10.58)* | 8.74(5.94–16.36)* | < 0.001 |
I-FABP (pg/mL) | 1112.55 ± 346.91 | 1443.33 ± 530.17 | 1914.30 ± 845.35* | 2055.32 ± 880.91* | 0.010 |
BMI, body mass index; AHI, apnea–hypopnea index; SaO2, pulse oxygen saturation; D-LA, D-lactic acid; I-FABP, intestinal fatty acid-binding protein.
values are expressed as mean ± standard deviation, median (interquartile range) or number (percentage).
p values based on Kruskal–Wallis or Chi-Squared (Fisher's Exact Test) or ANOVA test.
*p values significant for the comparison of OSA groups versus No OSA Subjects.