Table 1.

Demographic, genetic, seizure, medication, and movement disorder data from caregiver report.

Patient ID	Age (months)	Sex	GNAO1 Variant	Age of seizure onset	Seizure frequency	Types of seizures	Current seizure medications	Movement disorder	Movement disorder medications
1	46	Female	p.G40W	First week of life	2 to 3 per week	Focal, GTC	Lacosamide, oxcarbazepine, gabapentin	Yes	None
2	150	Male	NR	My child has never had seizures	NA	NA	NA	Yes	Levetiracetam, trazodone, tetrabenazine, clonazepam
3	32	Female	NR	My child has never had seizures	NA	NA	NA	Yes	None
4	31	Male	p.E246K	My child has never had seizures	NA	NA	NA	Yes	Tetrabenazine, diazepam
5	38	Female	p.R209H	My child has never had seizures	NA	NA	NA	Yes	None
6	14	Male	p.Q52P *Novel variant in this study	First week of life	20 per day	Infantile spasms, tonic, GTC	Levetiracetam, phenytoin, diazepam, clobazam	No	NA
7	22	Male	p.G203R	Less than 1 year of age	Seizure free	Infantile spasms, focal, GTC	Vigabatrin	Not sure	None
8	60	Female	NR	First week of life	Seizure free	Focal, tonic, GTC	Gabapentin, perampanel	Yes	Chlorprothixene
9	48	Male	p.G203R	Less than 1 year of age	10 per day	Infantile spasms	Clobazam, clonazepam, vigabatrin, oxcarbazepine, valproic acid, levetiracetam	Yes	Clobazam, clonazepam
10	72	Female	p.G203R	First week of life	1 per week	Tonic, GTC	Gabapentin, lacosamide, clobazam	Yes	Clobazam
11	72	Male	p.G203R	Less than 1 year of age	30 per day	Absence, focal, tonic, GTC	Valproic acid, lamotrigine, clobazam	Yes	Baclofen
12	51	Female	p.G203R	First week of life	Varies significantly	Not sure	Clonazepam, topiramate	Yes	Clonazepam
13	20	Male	p.G203R	First week of life	1 per week	Focal, GTC	Valproic acid, ketogenic diet	Yes	None
14	20	Female	p.E237K	My child has never had seizures	NA	NA	NA	Yes	None
15	24	Female	NR	My child has never had seizures	NA	NA	NA	Yes	Valproic acid

Abbreviations: NR, not reported; NA, not applicable; GTC, generalized tonic clonic seizure.