Table 3.

Univariate and Multivariate Logistic Regression Analyses of ICU Admission Adjusted for Age and Sex.

Variables	Univariate analysis			Multivariate analysis
	Odds ratio	p value		Odds ratio	p value
	(95% CI)			(95% CI)
Body mass index	1.06 (0.98-1.15)	0.17
Days from symptom onset to admission*	0.90 (0.83-0.99)	0.03
Diabetes	1.20 (0.64-2.25)	0.57
Cardiovascular disease	0.73 (0.33-1.57)	0.42
Chronic kidney disease	2.13 (0.50-8.98)	0.31
Chronic obstructive pulmonary disease	1.46 (0.70-3.01)	0.31
Interstitial lung disease	3.15 (1.12-8.86)	0.03		2.76 (0.78-9.81)	0.12
White blood cells	1.000 (0.999-1.001)	0.58
Lymphocytes	1.000 (0.999-1.001)	0.99
Platelets	0.95 (0.91-0.99)	0.04		0.99 (0.93-1.04)	0.64
Lactate dehydrogenase	1.003 (1.000-1.005)	0.04		1.004 (1.001-1.007)	0.01
Creatine	0.88 (0.33-2.33)	0.80
C-reactive protein	1.03 (0.99-1.08)	0.20
Corticosteroid/antiviral agents	0.57 (0.31-1.03)	0.06
Corticosteroid/antiviral agents/tocilizumab	4.12 (2.06-8.25)	<0.01		3.58 (1.69-7.56)	<0.01
Corticosteroid/antiviral agents/baricitinib	0.67 (0.27-1.67)	0.39
Days from symptom onset to the initiation of corticosteroid administration	0.85 (0.76-0.95)	<0.01		0.86 (0.75-0.99)	0.03
SpO2 to FiO2 ratio at the initiation of corticosteroid administration	0.998 (0.994-1.002)	0.26
Dose of methylprednisolone<80 mg	1.18 (0.57-2.43)	0.65
80 mg ≤ dose of methylprednisolone<250 mg	1.08 (0.56-2.06)	0.83
250 mg ≤ dose of methylprednisolone	0.98 (0.54-1.77)	0.94
Dexamethasone	1.28 (0.58-2.83)	0.55
Prednisolone	0.56 (0.11-2.82)	0.48
Methylprednisolone	1.15 (0.58-2.29)	0.70

CI: confidence interval, ICU: intensive care unit, SpO₂: oxygen saturation, FiO₂: a fraction of inspiratory oxygen

*“Days from symptom onset to admission” was not included in the multivariate analysis due to co-linearity with “days from symptom onset to the initiation of corticosteroid administration” (r=0.860, p<0.01).