Figure 5.

T lymphocyte infiltration of the pancreas. HE staining showed neutrophil infiltration and acinar-ductal metaplasia adjacent to the immunostaining sections (A). With anti-CD20 Immunostaining, there were only a few CD20-positive B lymphocytes in a high-magnification field (B). There were abundant CD3-positive T lymphocytes detected with anti-CD3 immunostaining (C). Anti-CD8 immunostaining showed that the T lymphocytes included CD8-positive cytotoxic T lymphocytes that had infiltrated the pancreas (D). Some T lymphocytes had directly infiltrated the acinar-ductal metaplasia (arrows) (D). HE: Hematoxylin and Eosin, CD: cluster of differentiation