Table 1.
Sample characteristics by SOMI stage.
| Entire | SOMI-0 | SOMI-1 | SOMI-2 | SOMI-3/4 | RISU | |
|---|---|---|---|---|---|---|
| N | 586 | 311 | 179 | 59 | 21 | 16 |
| Age | 67.4 (9.1) | 65.2 (9.3) | 69.3 (8.1) | 70.4 (7.4) | 67.7 (9.0) | 76.4 (8.7) |
| Education | 16.1 (2.6) | 16.1 (2.5) | 16.2 (2.6) | 15.4 (2.8) | 15.2 (2.9) | 16.4 (2.8) |
| Female, N (%) | 334 (57.0%) | 214 (68.8%) | 77 (43.0%) | 27 (45.8%) | 11 (52.4%) | 5 (31.3%) |
| APOE4+, N (%) | 198 (33.8%) | 104 (33.4%) | 60 (33.5%) | 22 (37.3%) | 9 (42.9%) | 3 (18.6%) |
| White, N (%) | 525 (89.6%) | 280 (90.0%) | 160 (89.4%) | 50 (84.8%) | 19 (90.5%) | 16 (100.0%) |
| MMSE | 29.2 (1.2) | 29.4 (0.9) | 29.0 (1.4) | 29.1 (1.1) | 28.4 (1.4) | 28.1 (2.2) |
| FSCRT-FR | 30.5 (5.9) | 35.0 (3.1) | 27.8 (1.8) | 22.3 (1.4) | 21.9 (6.1) | 17.0 (1.6) |
| FSCRT-TR | 47.8 (1.0) | 48.0 (0.2) | 47.9 (0.3) | 47.8 (0.4) | 44.1 (3.2) | 47.6 (0.5) |
| TMT-B | 77.7 (31.8) | 72.0 (30.1) | 80.4 (31.1) | 89.7 (33.2) | 96.3 (40.3) | 91.9 (28.45) |
| CSF Aβ42/Aβ40 | 0.078 (0.020) | 0.081 (0.018) | 0.076 (0.021) | 0.076 (0.024) | 0.073 (0.025) | 0.074 (0.023) |
| CSF p-Tau, pg/mL | 39.7 (22.8) | 37.0 (20.8) | 40.7 (23.3) | 44.5 (25.2) | 48.4 (29.4) | 52.6 (27.9) |
| CSF t-Tau, pg/mL | 304.1 (174.5) | 278.7 (149.8) | 322.8 (194.9) | 329.9 (171.6) | 352.0 (203.0) | 430.4 (251.3) |
| HVa, cm 3 | 7.67 (0.96) | 7.79 (0.90) | 7.69 (0.95) | 7.34 (0.90) | 7.30 (1.23) | 6.79 (1.02) |
Note. 1Values are mean (SD) unless otherwise noted. Abbreviations: Aβ= β-amyloid; RISU= retrieval impaired storage unimpaired; APOE4= apolipoprotein E ε4 allele; FSCRT= free and cued selective reminding test, FCSRT-FR: Free-recall part of FCSRT; FCSRT-TR=total recall part of the FCSRT; MMSE= mini-mental state Exam; TMT-B=Part B of the Trail Making Test (higher scores = worse performance); HVa=adjusted hippocampal volume; RISU=retrieval impaired storage unimpaired; t-tau=total Tau; p-Tau=phosphorylated tau