Table 2.

Multiple regression models for five using SOMI, APOE4 status, age, sex, and education as dependent variables and biomarker outcomes as dependent variables. Each outcome has a model with and without interaction terms between SOMI and APOE4 where SOMI-0 is the reference stage for SOMI.

		Predictors
Outcome	Interaction Term	APOE4		SOMI-1		SOMI-2		SOMI-3/4		APOE4*SOMI-1		APOE4*SOMI-2		APOE4*SOMI-3/4		Age		Sex		Education
		β	p	β	p	β	p	β	p	β	p	β	p	β	p	β	p	β	p	β	p
CSF Aβ42/Aβ40	N	−0.87	<0.001	−0.11	0.205	−0.01	0.929	−0.20	0.295							−0.32	<0.001	−0.08	0.327	0.01	0.694
	Y	−0.78	<0.001	−0.09	0.404	0.16	0.299	0.00	0.999	−0.06	0.716	−0.47	0.062	−0.50	0.207	−0.31	<0.001	−0.07	0.373	0.01	0.758
CSF p-Tau	N	0.32	<0.001	0.04	0.668	0.15	0.282	0.39	0.065							0.32	<0.001	0.10	0.234	−0.03	0.524
	Y	0.17	0.137	−0.05	0.642	0.05	0.763	−0.09	0.748	0.25	0.167	0.26	0.337	1.14	0.007	0.32	<0.001	0.08	0.350	−0.02	0.565
CSF t-Tau	N	0.24	0.003	0.15	0.092	0.14	0.318	0.32	0.126							0.28	<0.001	0.10	0.237	−0.04	0.291
	Y	0.05	0.637	0.01	0.922	0.05	0.765	−0.04	0.891	0.42	0.024	0.24	0.378	0.88	0.039	0.28	<0.001	0.08	0.335	−0.04	0.295
HVa	N	−0.04	0.559	0.10	0.228	−0.18	0.137	−0.38	0.051							−0.51	<0.001	−0.09	0.252	0.02	0.572
	Y	0.07	0.479	0.15	0.144	−0.09	0.543	0.15	0.541	−0.12	0.472	−0.25	0.320	−1.26	0.001	−0.51	<0.001	−0.07	0.391	0.02	0.643
PIB-PET MCBP	N	0.57	<0.001	0.15	0.244	0.11	0.593	0.17	0.654							0.34	<0.001	−0.09	0.440	−0.02	0.771
	Y	0.52	0.001	0.18	0.240	−0.15	0.542	0.10	0.829	−0.08	0.749	0.81	0.053	0.21	0.789	0.34	<0.001	−0.09	0.422	−0.01	0.920

β = standardized regression coefficient; CSF = cerebrospinal fluid; HVa = adjusted hippocampal volume; PIB-PET MCBP = Pittsburgh compound B uptake positron emission tomography of the mean cortical binding potential with partial volume correction.