Table 2.
Number and proportion of identified pro-tumorigenic and tumor suppressor proteins in acquired explorative pancreatic dataset. The acquired dataset described and analyzed in Fig. 3 was screened for commonly known (a) pro-tumorigenic and (b) tumor suppressor proteins in tissues of PDAC, CP and Normal Pancreas. Listed values represent the percentage of samples in which the respective Protein Of Interest (POI) has been identified as well as the corresponding absolute number of samples in brackets.
| a) | Pro-tumorigenic Protein | Proportion of PDAC Samples identifying POI (total n=14) | Proportion of CP Samples identifying POI (total n=7) | Proportion of Normal Pancreas Samples identifying POI (total n=15) |
|---|---|---|---|---|
| ADAM9 | 57.1 % (10) | 14.3 % (1) | 6.7 % (1) | |
| AGR2 | 100.0 % (14) | 100.0 % (7) | 100.0 % (15) | |
| AKT2 | 57.1 % (8) | 28.6 % (2) | 20.0 % (3) | |
| CDH1 | 100.0 % (14) | 100.0 % (7) | 100.0 % (15) | |
| ERBB2 | 28.6 % (4) | 0.0 % (0) | 13.3 % (2) | |
| KRAS | 92.9 % (13) | 71.4 % (5) | 33.3 % (5) | |
| MSLN | 35.7 % (5) | 0.0 % (0) | 0.0 % (0) | |
| S100A4 | 100.0 % (14) | 100.0 % (7) | 93.3 % (14) | |
| S100A6 | 85.7 % (12) | 71.4 % (5) | 60.0 % (9) | |
| S100P | 100.0 % (14) | 85.7 % (6) | 46.7 % (7) |
| b) | Tumor Suppressor Protein | Proportion of PDAC Samples identifying POI (total n=14) | Proportion of CP Samples identifying POI (total n=7) | Proportion of Normal Pancreas Samples identifying POI (total n=15) |
|---|---|---|---|---|
| EPB41L3 | 100.0 % (14) | 100.0 % (7) | 100.0 % (15) | |
| MAP2K4 | 92.9 % (13) | 71.4 % (5) | 93.3 % (14) | |
| NDRG2 | 92.9 % (13) | 85.7 % (6) | 86.7 % (13) | |
| PDCD4 | 100.0 % (14) | 100.0 % (7) | 100.0 % (15) | |
| SMAD4 | 71.4 % (10) | 42.9 % (3) | 60.0 % (9) |