Table 2. Amino acid, vitamin, and cofactor biosynthesis capabilities of G. haimaensis holobiont inferred from multi-omics analyses.

Nutrient	Host	Epibiont	Endosymbiont
++: complete gene set; +: incomplete gene set; -: missing gene set. Full gene list and completeness of biosynthesis gene sets are shown in Supplementary Figure S16 and Table S9. A: alanine; C: cysteine; Cho: chorismate; D: aspartate; E: glutamate; F: phenylalanine; G: glycine; H: histidine; HS: homoserine; I: isoleucine; K: lysine; L: leucine; M: methionine; N: asparagine; Orn: ornithine; P: proline; Q: glutamine; R: arginine; S: serine; T: threonine; V: valine; W: tryptophan; Y: tyrosine.
Biosynthesis of amino acids
A, D, G, N, P, Q, R	++	++	++
C, H, HS, I, L, T, V	+	++	++
Cho, E, F, K, Orn, W, Y	−	++	++
S	++	+	++
M	+	+	+
Biosynthesis of vitamins and cofactors
FAD, CoA, NAD, isopentenyl diphosphate	++	++	++
Glutathione	++	−	++
Protoheme	+	++	++
Pyridoxine, folate, lipoic acid, ubiquinone	+	+	++
Riboflavin	−	++	++
Biotin, thiamine	−	+	++
Siroheme	−	−	++
Pantothenate, pyridoxine phosphate	−	+	+