Figure 4.

Validation of circRNA biomarkers and host genes in Asian ICC tumor tissues collected by independent studies

(A) Abundance of circ-ADAMTS6, circ-PTPN22, and CDR1as in the ICC tumor tissues and adjacent tumor tissues collected by the GSE181523 (southern China) dataset and the GSE148561 (northern China) dataset. (B) Correlation between the abundance of circ-ADAMTS6 and circ-PTPN22 in ICC tumor tissues and adjacent normal tissues collected by the GSE181523 and GSE148561. (C) Expression of ADAMTS6 and PTPN22 in subgroups 1, 2, and 3, and adjacent normal tissues. (D) UMAP embedding of the single-cell transcriptome of ICC tumor tissues. (E) Expression of PTPN22, ADAMTS6, and immune checkpoint genes in different cell types.