Figure 3.

Subretinal gene therapy of BBS10 preserves significant rod and cone functions over the course of 10.5–12 months

(A–C) Rod function was measured by 0.01 cd s/m² dim flash after dark adaptation (DA). At 1.5 MP treatment, the treated eye had superior function compared with the untreated eye (A), and this response was sustained over 10.5 months, as the response in the untreated eye became non-recordable (B). Treated eyes had higher b-wave magnitudes compared with untreated eyes (C). (D–G) Combined rod-cone function was measured by 3.0 cd s/m² bright flash under dark-adapted conditions. At 1.5 MP treatment, the treated eye had a superior response (D), which was sustained over 10.5 months as the response in the untreated eye became non-recordable (E). Treated eyes had higher a- (F) and b- (G) wave amplitudes in combined response ERGs. Datapoints shown are averages ± standard error of the mean. p values of treatment effect using two-way ANOVA are shown.