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. 2023 Jan;64(1):109–116. doi: 10.2967/jnumed.122.263962

TABLE 1.

Summary of Mouse Experiments

Treatment Cells injected Cures (n)
Group 1 1 × 106 0/5
 Untreated
 213Bi-rituximab, 925 kBq (day 7) 1 × 106 0/5
 213Bi-rituximab, 3,700 kBq (day 7) 1 × 106 0/5
 213Bi, free, 1,295 kBq (day 7) 1 × 106 0/5
 213Bi-HER2/neu, 1,295 kBq (day 7) 1 × 106 0/5
 10 μg of rituximab (day7) 1 × 106 0/5
Group 2 5 × 105 0/6
 Untreated
 213Bi-rituximab, 2,775 kBq (day 7) 5 × 105 2/6
 213Bi-rituximab, 2,775 kBq (days 7, 13) 5 × 105 3/7
 10 μg of rituximab (days 7, 13) 5 × 105 1/4
 213Bi-HER2/neu, 2,775 kBq (day 7) 5 × 105 0/5
Group 3 1 × 106 0/6
 Untreated
 213Bi-rituximab, 2,775 kBq (day 7) 1 × 106 0/6
 213Bi-rituximab, 2,775 kBq (days 7, 12) 1 × 106 0/6
 213Bi-rituximab, 2,775 kBq (days 7, 12, 19) 1 × 106 0/6
Group 4 1 × 106 0/8
 Untreated
 213Bi-rituximab, 3,700 kBq (day 4) 1 × 106 6/8
 131I-tositumomab, 2,035 kBq (day 4) 1 × 106 6/8
 90Y-rituximab, 925 kBq (day 4) 1 × 106 0/8
 10 μg of rituximab (day 4) 1 × 106 1/8