Group 1 |
1 × 106
|
0/5 |
Untreated |
213Bi-rituximab, 925 kBq (day 7) |
1 × 106
|
0/5 |
213Bi-rituximab, 3,700 kBq (day 7) |
1 × 106
|
0/5 |
213Bi, free, 1,295 kBq (day 7) |
1 × 106
|
0/5 |
213Bi-HER2/neu, 1,295 kBq (day 7) |
1 × 106
|
0/5 |
10 μg of rituximab (day7) |
1 × 106
|
0/5 |
Group 2 |
5 × 105
|
0/6 |
Untreated |
213Bi-rituximab, 2,775 kBq (day 7) |
5 × 105
|
2/6 |
213Bi-rituximab, 2,775 kBq (days 7, 13) |
5 × 105
|
3/7 |
10 μg of rituximab (days 7, 13) |
5 × 105
|
1/4 |
213Bi-HER2/neu, 2,775 kBq (day 7) |
5 × 105
|
0/5 |
Group 3 |
1 × 106
|
0/6 |
Untreated |
213Bi-rituximab, 2,775 kBq (day 7) |
1 × 106
|
0/6 |
213Bi-rituximab, 2,775 kBq (days 7, 12) |
1 × 106
|
0/6 |
213Bi-rituximab, 2,775 kBq (days 7, 12, 19) |
1 × 106
|
0/6 |
Group 4 |
1 × 106
|
0/8 |
Untreated |
213Bi-rituximab, 3,700 kBq (day 4) |
1 × 106
|
6/8 |
131I-tositumomab, 2,035 kBq (day 4) |
1 × 106
|
6/8 |
90Y-rituximab, 925 kBq (day 4) |
1 × 106
|
0/8 |
10 μg of rituximab (day 4) |
1 × 106
|
1/8 |