Figure 2.

Oxidized corn oil changes the liver lipid metabolism of broilers by upregulating PPARα. The results clearly showed that naturally oxidized corn oil could damage liver lipid metabolism and accelerate lipid deposition of broilers by upregulating PPARα. Additionally, naturally oxidized corn oil could cause liver inflammation and damage the liver by activating the NF-κB signaling pathway. In this case, the body could improve antioxidant capacity by activating Nrf2 signaling pathway and resist the negative effects caused by the addition of oxidized oil to a certain extent, but its mechanism needs to be further explored. Abbreviations: NF-κB, nuclear factor kappa B; Nrf2, nuclear factor erythroid related factor 2; PPARα, peroxisome proliferators activate receptor-α; ROS, reactive oxygen species.