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Chemical structures of the nNF derivatives. The most active derivatives nNF-C2 and nNF-C4 displayed MIC90 values against actively-replicating (AR) M. tuberculosis of 0.062 μg/ml and 0.125 μg/ml respectively, and MBC90 values of 0.5 μg/ml against non-replicating (NR) M. tuberculosis H37Rv, respectively.
