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. Author manuscript; available in PMC: 2023 Jan 16.
Published in final edited form as: ACS Biomater Sci Eng. 2020 Nov 4;6(12):6808–6818. doi: 10.1021/acsbiomaterials.0c00788

Figure 2.

Figure 2.

hiPSC-derived CM sheet and dPMS interactions. (A) Comparison of native porcine myocardial slice (nPMS) and decellularized porcine myocardial slice (dPMS) with the same thickness (600 μm). (B) Schematic demonstration of lateral and bilateral seeding of hiPSC-derived CM sheets onto dPMS. (C) CMs distributions 1 day after lateral and bilateral seeding of prestained hiPSC-derived CM sheets onto dPMS. (D) Cell seeding efficiency of using cell suspension and two types of CMs sheets (0.8 × 106 total cells/sheet and 1.6 × 106 total cells/sheet). (E) Migration distance of the CMs from the seeded CM sheet in dPMS. There are no statistically significant differences in terms of total migration distance between the groups of CM sheet (0.8 × 106 cells) and CM sheet (1.6 × 106 cells) at all the assessed time points (day 0, 1, 7, and 14). (F) Cell viability after seeding hiPSC-derived CM sheets to dPMS. *Represents the statistically significant difference among the experiment groups with p-value less than 0.05 (n = 6). Scale bar: 100 μm.